On the one hand, patients with primary ITP have higher circulating levels of neutrophil extracellular traps (NETs), E-selectin, plasminogen activator inhibitor-1 (PAI-1) and microparticles rich in phosphatidylserine and tissue factor (TF), as well as hyperreactive immature platelets, within a proinflammatory scenario that also promotes coagulation, occasionally boosted by lupus anticoagulant and/or anticardiolipin or anti-β2-glycoprotein-I antibodies [122,123,124]. The gene discussed is SERPINE1; the disease is autoimmune thrombocytopenic purpura.