After adjusting for the confounding factors, the polymorphisms of rs4841588 (GG/TT: aOR = 0.41, 95% CI: 0.24–0.70; additive model: aOR = 0.77, 95% CI: 0.62–0.95; recessive model: aOR = 0.41, 95% CI: 0.25–0.69), rs12458 (AA/GG: aOR = 2.20, 95% CI: 1.50–3.23; AG/GG: aOR = 1.87, 95% CI: 1.34–2.60; dominant model: aOR = 1.98, 95% CI: 1.45–2.69; additive model: aOR = 1.49, 95% CI: 1.23–1.81; recessive model: aOR = 1.48, 95% CI: 1.08–2.04), and rs904018 (additive model: aOR = 0.81, 95% CI: 0.66–0.99) of the GATA4 gene were significantly related to CHD (p < 0.05). The gene discussed is GATA4; the disease is coronary artery disorder.