Activated platelets release numerous proteins, such as p-selectin, beta-thromboglobulin (β-TG), platelet factor 4 (PF-4), thromboxane A2 (TxA2), RANTES, CD40L, and several other molecules, which can potentially be used as biomarkers for cardiovascular disease [10,11]. This evidence concerns the gene PF4 and cardiovascular disorder.