SCD and obesity due to melanocortin 4 receptor deficiency: Stearoyl-CoA desaturase-1 (Scd1), an obesity-linked enzyme essential for the synthesis of mono/polyunsaturated fatty acids, was enhanced by the HFD (diet effect, F (1, 20) = 8.47; p < 0.01, Figure 5C) but, once again, it was not affected by LEA treatment.