CASP3 and Hyperglycemia: The relationship between hyperglycemia and the induction of apoptosis has already been established, and studies have reported the presence of excess apoptosis in the ovarian cells of diabetic rats [22,83,85] and in the ovaries of rats that consumed an HFD by increasing the expression of Bax and caspase-3 in addition to other apoptotic markers [18,52,86,87].