Additionally, as compared to livers from ethanol-fed mice, there was a significant reduction in the number of activated macrophages as seen by markedly fewer F4/80 positive (brown color-stained cells) Kupffer cells in mice administered TB (Figure 1D) with the concomitant decrease in systemic endotoxin levels (Figure 1E) and markers of liver injury (AST/ALT ratio) (Figure 1F). Here, GPT is linked to tuberculosis.