Two-way analysis of variance analysis of the area of distribution of Iba1-positive cells revealed a significant effect of obesity (F (1, 88) = 285.1; p < 0.0001) and OEA-DS administration (F (1, 88) = 363.8; p < 0.0001), and a significant interaction effect of these factors (F (1, 88) = 326.7; p < 0.0001) in both white pulp and red pulp: A significant effect of obesity (F (1, 88) =364.6; p < 0.0001), OEA-DS application (F (1, 88) = 259.9; p < 0.0001), factor interaction (F (1, 88) = 297.4; p < 0.0001) was found. This evidence concerns the gene AIF1 and obesity due to melanocortin 4 receptor deficiency.