CD68 and obesity due to melanocortin 4 receptor deficiency: For CD68, significant effects of obesity (F (1, 76) = 139.5; p < 0.0001) and OEA-DS application (F (1, 76) = 43.47; p < 0.0001), and a significant interaction effect of these factors (F (1, 76) = 38.46; p < 0.0001) were found in both the white and red pulp.