In contrast, for IL-6 and IL-1β, there were significant effects of both obesity (F (1, 8) = 51.03, p < 0.0001 for IL-6; F (1, 8) = 35.11, p = 0.0004 for IL-1β) and OEA-DS administration (F (1, 8) = 11.75, p = 0.0090 for IL-6; F (1, 8) = 5.567, p = 0.0460 for IL-1β ), and their interactions (F (1, 8) = 12.883, p = 0.0071 for IL-6; F (1, 8) = 13.03, p = 0.0069 for IL-1β). The gene discussed is IL1B; the disease is obesity due to melanocortin 4 receptor deficiency.