ADIPOQ and inflammatory response: There were no differences in the leptin and adiponectin concentrations between the two groups at initial and annual assessment; however, there was a significant reduction in the leptin concentrations and a significant increase in the adiponectin concentrations in both groups of participants following the implementation of the lifestyle intervention program, which is consistent with the reduction in adipose inflammation (p < 0.01) (Table 3; Figure 2).