Patients who required non-invasive ventilation (NIV) had greater anemia (p = 0.003) and lymphopenia (p = 0.005), higher values of PCT (p = 0.008) and LDH (p = 0.006) and lower levels of albumin (p = 0.008) and HDL cholesterol (p = 0.012). This evidence concerns the gene ALB and lymphopenia.