The present report describes a female TSC patient with a confirmed heterozygous pathogenic genotype, NG_005895.1 (<i>TSC2</i>_v001): c.2640-1G>T, who presented with uncommon large and bilateral FCPs causing bilateral ptosis and marked with hyperostosis of the diploe that generated an asymmetry of the brain parenchyma. This evidence concerns the gene TSC2 and tuberous sclerosis.