They concluded that the overexpression of p53 in papillary low-grade TCC and invasive high-grade TCC and the lack of p53 expression in PUNLMP indicate that mutations of the p53 gene are not usually associated with the development of urothelial neoplasms and may play a crucial role only in progression of PUNLMP to a higher-grade TCC [23]. The gene discussed is TP53; the disease is tarsal-carpal coalition syndrome.