IGHE and allergic disease: In a study by Broeckman et al., we observed that shrimp-allergic patients with a food allergy to mealworms exhibited IgE reactivity by basophil activation test (BAT), ImmunoCAP Specific IgE test, and Western blotting to all insect extracts, and the primary IgE binding proteins were tropomyosin and/or arginine kinase [27].