ACKR3 and colorectal carcinoma: A recent paper described that the activation of CXCL12/CXCR7 promoted miR-146a-5p and miR-155-5p, derived from the exosome in CRC cells, to enhance the activation of CAFs via the JAK2-STAT2/NF-κB signaling pathway and further promote EMT and CRC metastasis to the lung [110].