TGF-β produced by Tregs suppresses the differentiation and growth of effector T cells, has a role in inhibiting the function and development of cytotoxic CD8+ T cells by repressing the tumor antigen processing and presentation of DCs, and inhibits CD8+ T cell proliferation through blocking the expression of IFN-γ and IL2 [95,96,97]. The gene discussed is TGFB1; the disease is neoplasm.