Mutations of PTEN are commonly known for the link to the PTEN hamartoma tumor syndrome (PHTS), which is characterized by a greater risk of cancer occurrence, includes Cowden syndrome (CS), Bannayan-Riley-Ruvalcaba syndrome (BRRS), and PTEN-related Proteus syndrome (PS) [135,136]. The gene discussed is PTEN; the disease is PTEN hamartoma tumor syndrome.