Though these milder forms of muscular dystrophy are classified as LGMD based on their progressive muscle wasting in the extremities, more severe congenital muscular dystrophies are associated with mutations in glycosyltransferases targeting α-dystroglycan that result in a non-progressive muscle weakness that is observed at birth (discussed in Section 6). This evidence concerns the gene DAG1 and limb-girdle muscular dystrophy.