LAMA2 and Congenital muscular dystrophy, Ullrich type: These dystrophies include LAMA2-related muscular dystrophy (MDC1A), caused by mutations in the α chain of laminin-211 (0.81 in 100,000 individuals worldwide), Ullrich congenital muscular dystrophy (UCMD) (0.13 per 100,000 individuals) and Bethlem myopathy (0.77/100,000 individuals), which are associated with mutations in the α chain of collagen VI (ColVI) (Figure 3) [200,201].