DUX4 and facioscapulohumeral muscular dystrophy: Treatment with a novel p300-specific spirocyclic HAT inhibitor, iP300w, effectively prevented the induction of DUX4 target genes, inhibited the harmful effects of DUX4, and reversed the accumulation of acetylated histone H3 in C2C12 cells and iDUX4pA mouse model of FSHD [125].