There are more than 260 polymorphic mutations in DYSF reported to result in three types of muscular dystrophies: limb-girdle autosomal recessive muscular dystrophy type 2B (LGMDR or LGMD2B), Miyoshi myopathy (MM), and distal myopathy with anterior tibial onset (DMAT) (Figure 2) [166]. Here, DYSF is linked to Miyoshi myopathy.