Over the past few decades, in efforts to assess disease activity and severity in patients with AP, several clinical and biochemical scoring systems as well as individual biomarkers have been proposed, such as the C-reactive protein (CRP) level, Bedside Index of Severity in Acute Pancreatitis (BISAP) score, Acute Physiology and Chronic Health Evaluation (APACHE-II) score, Ranson score, Glasgow score, systemic inflammatory response syndrome (SIRS) score, and Pancreatitis Activity Scoring System (PASS) score [7,8,9,10]. The gene discussed is CRP; the disease is systemic inflammatory response syndrome.