In addition to the role of MORC2 in DNA repair and response, MORC2 also plays a quintessential role in regulating cancer cell proliferation, such as (i) PAK1-mediated MORC2 phosphorylation, which is required to promote gastric cancer cell proliferation by facilitating G1–S transitions and (ii) O-GlcNAcylated MORC2, which is induced by TGF-β1 treatment, recruits TGF-β1 target genes (CTGF and SNAIL) and plays a requisite role in their transcriptional activation by an unknown mechanism, promoting breast cancer invasion and migration [24]. The gene discussed is TGFB1; the disease is cancer.