Another dominant variant at position Met163, p.Met163Val, which is associated with non-syndromic (isolated) hearing loss, was investigated by Press et al. (2017), along with syndromic or non-syndromic dominant variants located in different Cx26 domains (p.Asn14Lys, p.Asp50Asn, p.Asn54Lys, and p.Ser183Phe). Here, GJB2 is linked to hearing loss disorder.