XDH and hyperuricemia: Meanwhile, in the recent PRIZE (program of vascular evaluation under uric acid control by xanthine oxidase inhibitor, febuxostat: multicenter, randomized controlled) study [91], 24 months of febuxostat, compared to non-pharmacological lifestyle modification care for hyperuricemia, did not delay the progression of CIMT in Japanese patients with asymptomatic hyperuricemia.