While the underlying mechanism is currently unknown, YAP and TAZ, the transcriptional coactivators and effectors of the Hippo signaling pathway, have been identified as downstream targets of an miR21-OTUD2-YAP/TAZ axis in hepatocellular carcinoma [158], thus, potentially linking OTUD2/YOD1 to glioma stem cell maintenance and proliferation [159]. The gene discussed is YOD1; the disease is glioma.