Table 1 shows the DUB genes that were most significantly different between the non-tumor group and each of the other three adult glioma groups. Seventeen of the ninety-nine DUB genes were differentially expressed (p < 0.001) between AS, ODG, and GBM (USP46, USP54, ZRANB1, USP1, OTUD7A, TNFAIP3, USP27x, USP30, EIF3H, USP49, OTUD1, USP11, OTUB1, CYLD, USP12, USP2, USP47, in order of p value as determined by ANOVA). This evidence concerns the gene USP46 and central nervous system cancer.