Gal-3 has been found to support tumor cell adaptation and survival in the stressful conditions of the TME by activating several cellular signaling pathways, such as RAS/MAPK, Nuclear Factor-kappa B (NF-kB), and Focal Adhesion Kinase (FAK)/Vascular Endothelial Growth Factor (VEGF) [76]. The gene discussed is LGALS3; the disease is neoplasm.