All these proteins have relevance to cancer (Supplemental material File 4), while BMP6, MSTN, SLITRK5 and 6 and ICAM4 and NPTX1 have specific relevance to GBM with, in the case of SLTGK5 and 6 and NPTX1 having been linked to neural tissue and neurodegeneration respectively. This evidence concerns the gene ICAM4 and cancer.