In its interaction with β-transducin repeat-containing E3 ubiquitin-protein ligase (β-TrCP), itself a substrate recognition subunit for the Skp1-Cullin1-F-box protein E3 ubiquitin ligase, it has been implicated in tumorigenesis and regulation of pathways with β-TrCP suppressing progression and cell migration in glioma. Here, SKP1 is linked to central nervous system cancer.