CYREN and cancer: Several predictive proteins identified have connections to known pathways in cancer, including PLCD3 (phospholipase C delta3), VARS1 (Valyl-tRNA synthetase 1), CYREN (Cell cycle regulator of NHEJ), KIR2DL4 (Killer cell immunoglobulin-like receptor 2DL4) and SKP1(S-phase kinase-associated protein 1), and have a direct link to GBM [56,57] (Supplemental File 4).