HIPK2 is an evolutionarily conserved protein kinase that modulates many molecular pathways involved in cell apoptosis, DNA damage response, protein stability, and protein transcription, and its deregulation contributes to cancer progression, invasion, and metastasis and reduces cancer cell response to drugs [24,25,26], other than to angiogenic and fibrotic diseases [27,28,29]. Here, HIPK2 is linked to cancer.