Interestingly, S100A8 and S100A9 proteins were also detected within our study, confirming that the S100A8/A9 complex has a role in HIE, and has been suggested to be involved in the amplification of neuroinflammation [29], and cerebral ischemia-reperfusion injury [30,31]. This evidence concerns the gene IGKV1D-22 and Cerebral ischemia.