POMC and Hypertension: Risk factors related to CSR are stress causing high dose cortisone and adrenocorticotropic hormone (ACTH) levels and hypertension, pregnancy, Cushing’s disease, etc. The exact cause of central serous retinopathy remains unclear, yet it is believed that pressure changes in the choroid layer may lead to damage of the retinal pigment epithelium (RPE), which in turn may result in the accumulation of fluid under the retina [7].