Moreover, in older patients, SIRT1 rs3818292 AG+GG genotypes and each G allele were associated with a 2.6-fold and 2.2-fold increased odds of MS occurrence under the dominant and allelic genetic models (OR = 2.578; CI: 1.282–5.181; p = 0.008; OR = 2.177; CI: 1.219–3.890; p = 0.009, respectively). The gene discussed is SIRT1; the disease is myeloid sarcoma.