Studies have revealed the crucial role of SIRTs, including SIRT1, in the interaction between neuroinflammation, neurodegeneration, and metabolic changes [9], and SIRT1 has been implicated in the pathogenesis of several neurological diseases such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease [17,18]. The gene discussed is SIRT1; the disease is juvenile Huntington disease.