The findings of genotypes and alleles of SIRT1 rs3818292, rs3758391, and rs7895833 in MS and control groups between different gender distributions suggest that, in women, the SIRT1 rs3758391 CC genotype and each C allele were less frequent in those with MS compared with the control group (62.8% vs. 45.7%, p = 0.002; and 79.9% vs. 69.2% p = 0.002, respectively). This evidence concerns the gene SIRT1 and myeloid sarcoma.