We demonstrated that tumor size, lymph node metastasis, incomplete enhancement and iso-enhancement of PED were independent predictors for HIF-1 α-high PDACs and GLUT1-high PDACs, and CEUS quantitative perfusion parameters, including PE and WIR values, were higher in HIF-1α-high PDACs and GLUT1-high PDACs. The gene discussed is HIF1A; the disease is neoplasm.