GPT and hepatocellular carcinoma: Accordingly, in a recent historical group study including 6949 non-cirrhotic patients without significant ALT increases (<2 × ULN at least for 1 year) irrespective of HBeAg positivity, the relation between the HBV DNA levels and HCC risk was not linear, but parabolic, demonstrating the highest HCC risk with extreme serum HBV DNA values of 5.0–7.0 log10 IU/mL and demonstrating the lowest HCC risk with HBV DNA levels of >8 log10 IU/mL and ≤4 log10 IU/mL, irrespective of the ALT levels [2].