Adding new variables, such as mutations and somatic variations, in copy number, genome and exome sequencing, and determining microsatellite instability (MSI), has helped to divide the new CE classification into 4 groups with different prognoses in terms of free survival of specific progression and risk of recurrence, namely Polymerase epsilon (POLE) ultramutated, MSI ultramutated, copy number (CN) low, and CN high [5]. This evidence concerns the gene POLE and cholesteryl ester measurement.