NOX4 and neoplasm: Muzza et al. [17] recently reported that ROS generation and NOX4 expression were higher in malignant and benign lesions than in normal tissues, and, among malignant lesions, a significant association was detected between oxidative stress and the aggressiveness of the tumor (i.e., increased levels of H2O2 in FTC and PDTC/ATC compared with PTC).