Some abnormal protein aggregation associated with neurodegenerative diseases, such as amyloid beta peptide (Aβ) in Alzheimer’s disease [52], α-synuclein in Parkinson’s disease [53], and SOD1 and TDP-43 [51] in ALS, are known to induce the activity of the NLRP3 inflammasome in a mouse model. Here, APP is linked to early-onset autosomal dominant Alzheimer disease.