Previous studies have shown that subacute ingestion of chlorogenic acids decreased sleep latency in clinical trials [43], and in vitro and in vivo studies have reported that it prevents cognitive decline and nerve damage through tumor necrosis factor (TNF) and nuclear factor erythroid 2 related factor 2 (Nrf2)-nuclear factor kappa-light-chain-enhancer of activated B (NF-κB) signaling pathways [44,45]. The gene discussed is NFE2L2; the disease is Mental deterioration.