DUOX2 and sclerosing cholangitis: DUOX2 expression was also upregulated in non-IBD inflammatory conditions such as primary sclerosing cholangitis (PSC) (Figure 5F) or non-IBD colitis (Figure 5G), indicating that changes in mucosal DUOX2 seem to be triggered by inflammation in general or even could be a causative trigger of the inflammation, yet further experiments are needed to disentangle these effects.