Namely, the abnormal epidermis differentiation/hyperproliferation is triggered by increased cytokines production (i.e., interleukin (IL)-12/23, IL-22, IL-17, tumor necrosis factor-alpha (TNF-α), IL-6, IL-4, IL-13, etc.)) that favor free radicals production, leading to diminishing already compromised non-enzymatic and enzymatic antioxidant system defense and creating a vicious circle between inflammation and redox imbalance in PsO and AD pathogenesis [1,9]. Here, TNF is linked to Alzheimer disease.