Finally, and given that MCC950, an NLRP3 inhibitor, reduced the emotional disorders associated with type 2 diabetes in mice [17], our data suggested that the anxiolytic and antidepressant properties of 1m, 1a, 1b, and DMF might in part also produced by blocking the activation of this inflammasome in the AMG. Here, NLRP3 is linked to type 2 diabetes mellitus.