NOS2 and cancer: Interestingly visfatin has been found to increase in human dental pulps with age [385], contributing to senescence, and is highly expressed in inflammatory diseases and some cancers [384]; however, the functional role of visfatin in aging has not yet been well established, but the protective melatonin effect against visfatin-induced inflammation through iNOS activation, strongly supports its use to treat the low-grade inflammatory condition.