The pancreatic cancer cell lines A818-6 and T3M4, expressing MCT1 at low and moderate level, respectively, and capable of adopting a reverse Warburg metabotype [39], were exposed to a normal (RPMI with 2 mM Gln) or glutamine-reduced (RPMI with 0.2 mM Gln) culture medium for various periods. The gene discussed is SLC16A1; the disease is familial pancreatic carcinoma.