Amyloid and tau deposits, metabolic dysfunction, and hyper-neuroinflammatory responses, including increased expression of tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β), IL-6, IL-8, and IL-10, caused by AD progression are involved in the exacerbation of synaptic loss and neuronal death [4]. Here, MAPT is linked to Alzheimer disease.