Mutations in the genes PRKN, PINK1, and DJ-1, all inherited in an autosomal recessive manner and directly linked with mitochondrial dysfunction, as well as autosomal dominant mutations in the genes LRRK2 and SNCA, have been implicated in the ‘oxidative stress’ hypothesis of PD etiology [69]. The gene discussed is LRRK2; the disease is Parkinson disease.