PON1 and coronary artery disorder: Interestingly, it has been reported that HDL from patients with coronary disease has a lower capacity to stimulate the endothelial production of NO as a result of a lower PON1 activity, in a mechanism that involves the activation of lectin-type oxidized LDL receptor 1 (LOX-1) and protein kinase C-βII (PKCβII) [40].