The analgesic effects produced by 1m, 1a, and 1b, as well as DMF, agreed with previous research revealing the painkiller properties of DMF in animals with arthritis [19]; those produced by another HO-1 inducer, cobalt protoporphyrin IX (CoPP), in mice with CFA-induced inflammatory pain [38,39]; and that made by lentivirus encoding HO-1 in animals with vincristine provoked neuropathic pain [40]. The gene discussed is HMOX1; the disease is Arthritis.