A prior study demonstrated that the DSI could be helpful for the preoperative prediction of human epidermal growth factor receptor 2 (HER2) in patients with breast cancer, with the finding that the AUC values of the DSI quantitative parameters (range from 0.67 to 0.72) were higher than that of the DTI metric apparent diffusion coefficient (AUC = 0.57) [82]. The gene discussed is ERBB2; the disease is breast carcinoma.