Reductions in Reelin levels and signaling have been found during aging, as well as having been associated with a number of neurological diseases, including ataxias, Alzheimer’s disease (AD), schizophrenia (SZ), and also being partially involved in autism and even traumatic brain injuries (TBI) [68,69,70,71]. This evidence concerns the gene RELN and early-onset autosomal dominant Alzheimer disease.