In addition, decreased levels of Reelin, together with early deficits in Reelin signaling, have been evidenced in the cerebrospinal fluid of patients with Ataxia-telangiectasia (A-T), and a decreased expression of the Reelin receptor was shown in a mouse model of A-T (Atm-/-) [83]. The gene discussed is RELN; the disease is Ataxia-telangiectasia.