BCO2 and early-onset autosomal dominant Alzheimer disease: It is also worth mentioning that many neurodegenerative disorders, including Alzheimer’s disease, often display coexistence with metabolic dysfunctions and that ablation of the β,β-Carotene-9’,10’-oxygenase 2 (BCO2) enzyme that catalyzes the asymmetric cleavage of carotenoids remodels the hypothalamic metabolome, leading to metabolic disorders in mice [66].