The other risk factors LOXL1, LOXL2, and STEAP3 were highly expressed in almost all tumor zones (CT, HBVs, MVP, PAN, PNZ, IT) and showed the lowest expression in the peritumor zone (LE), while the protective factor F5 showed no obvious change between the tumor and peritumor zone. The gene discussed is LOXL1; the disease is neoplasm.