Chemokine receptor 5 (CXCR5) contributed to cognitive impairment in SAE mice via the enhancement of p38MAPK/NF-κB/STAT3 signaling, and it was found that CXCR5 knockouts restored autophagy, polarized microglia to the M2 phenotype, and inhibited the release of proinflammatory cytokines in the hippocampus by inhibiting p38MAPK and CXCR5 [93]. This evidence concerns the gene CXCR5 and Cognitive impairment.