In the case of mouse NF1-OPG, CD8+ T cells are involved in neuron-mediated T cell CCL4 production and subsequently induce microglial CCL5 secretion to support tumor growth, and the depletion of CD8+ T cells suppressed tumor growth [86], thereby suggesting that CD8+ T cells could be a therapeutic target in the optic nerve for patients with OPG. Here, NF1 is linked to neoplasm.