Because surgery may damage the optic pathway and radiation imposes risks for secondary malignancies and cognitive issues in NF1-OPG, the first line treatment for NF1-OPG is chemotherapy, which often involves platinum-based and vinca alkaloids-based chemotherapy agents (e.g., carboplatin and vincristine) that target the neoplastic (tumor) cells [13,90,91,92,93,94,95]. This evidence concerns the gene NF1 and neoplasm.