However, the study of OPG in larger animal or non-human primates remains an unmet need, despite the recent development of NF1 pig models [110,111] Whereas survival for patients with OPG is excellent, no effective treatments for OPG-induced visual impairment are currently available [8,41,49,50,112,113], likely because tumor-induced RGC loss cannot be reversed. Here, NF1 is linked to neoplasm.