One such model, Nf1OPG (Nf1flox/−; Gfap-Cre) mice, recapitulates the genetics of NF1 patients: the mice harbor a germline Nf1 mutation in all cells and a second-hit Nf1 loss in the glioma-initiating neural stem cells [34]. Here, GFAP is linked to central nervous system cancer.