In ROSMAP, higher brain DNA methylation at the same two markers, i.e., cg00574958 and cg17058475 (CPT1A), is significantly associated with higher CERAD scores (P = 5 × 10−4 and P = 0.001, respectively), and suggestively with higher Braak stage (P = 0.004 and P = 0.01, respectively) and greater risk of cognitive impairment (P = 0.005 and P = 0.02, respectively), Table 4. Here, CPT1A is linked to Cognitive impairment.