In FHS, higher levels of blood DNA methylation at cg15150970 (DNMT3A) were associated with higher IR, aligned with previous studies [71], and with reduced AD risk, as found in a recent meta-analysis of blood EWAS of AD conducted in two independent samples (Additional file 1: Table 18), [26] suggesting a potentially different epigenetic mechanism underlying IR and AD in the periphery. Here, DNMT3A is linked to Alzheimer disease.