CTSD and dementia: In addition, blood DNA methylation levels at cg17901584 (DHCR24), cg00574958 and cg17058475 (CPT1A), cg12729894 (CTSD), cg11024682 (SREBF1), and cg06500161 (ABCG1) have been reported as strongly associated with CAIDE1, [74] a dementia composite risk score calculated using a weighted sum of age, sex, BMI, years in education, systolic blood pressure, and total cholesterol [75].