In a recent meta-analysis combining six EWAS of AD using DNA methylation measured in different brain regions and across cortex [28], DNA methylation levels at both cg00574958 and cg17058475 (CPT1A) were reported to be positively associated with AD (Braak stage) in most studies, and similar effects were observed across brain regions (Additional file 1: Figure S5). Here, CPT1A is linked to Alzheimer disease.