It is worth to mention that diabetes personals' wound healing could also be affected by decreased microperfusion, structural protein breakdown, and reduced neutrophil chemotaxis and phagocytosis. For example, it has been shown that VSD therapy could increase would healing through promoting granulation and angiogenesis partly by increasing expression of vascular endothelial growth factor (VEGF) in diabetic foot ulcer [7]. Here, VEGFA is linked to diabetes mellitus.