We examined TMEM147 expression in 72 HCC tissues and 28 non-tumor liver tissues, and found that the TMEM147 protein staining rate in HCC tissues was 83.3% (60/72) compared to 10.7% (3/28) in normal liver tissues (Fig. 1c), and the protein expression level of TMEM147 in the HCC cohort was significantly correlated with patient survival (Fig. 1I). The gene discussed is TMEM147; the disease is neoplasm.