DHCR7 and gastric cancer: For example, elevated DHCR7 expression indicates a poor prognosis for cervical cancer [10]; DHCR7 promotes tumorigenesis by activating the PI3K/AKT/mTOR signaling pathway in bladder cancer [11]; mutations in DHCR7 are significantly associated with the circulating 25-hydroxyvitamin D concentration and the risk of ovarian cancer development in Europeans [12]; proliferation, migration, and invasion of GC cells are reduced by DHCR7 knockdown but increased by DHCR7 overexpression both in vivo and in vitro [13].